Reversible epigenetic changes within the loci of genes that regulate critical cell processes have recently emerged as important biomarkers of disease pathology. It is then natural to consider the consequences for population health risk of such epigenetic changes during the aging process. Specifically, the interplay between dynamic methylation changes that accompany aging and mutations that accrue in an individual’s genome over time needs further investigation. The current study investigated the role of dynamic methylation acting together with gene variants in an individual over time to gain insight into the evolving epigenome–genome interplay that affects biochemical pathways controlling physiological processes during aging. We completed whole-genome methylation and variant analysis in a non-smoking Zoroastrian-Parsi individual, collecting two samples, 12 years apart (at 53 and 65 years respectively) (ZPMetG-Hv2a-1A (old, t0), ZPMetG-Hv2a-1B (recent, t0+12)) and analyzing them using a GridION Nanopore sequencer at 13X genome coverage overall…….READ MORE

POSTED BY News | Apr, 08, 2022 |